Figure 1From: The silent defense: Micro-RNA directed defense against HIV-1 replicationOutlines the restriction on virus replication imposed by host cell RNAi response. Intact RNAi response, or over expression of miR-17/miR-2a severely restricts HIV-1 replication. Host proteins targeted by miRNAs include PCAF, a HIV-1 Tat-cofactor, its expression favors HIV-1 replication.Back to article page