Skip to main content

Table 1 Mutations in RT detected in virus isolated from RT-SHIV infected macaques.

From: Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection

Animal number

Time of Infection (weeks)

Codon 65 mutation

Codon 70 mutation

Other RT mutations

30007

21 (Tx)

-

-

V75L, G196R, M357T/M

 

23

-

-

V75L, G196R

 

25

-

K70E

G196R, L214F, M357T

 

29

K65R/K

-

G196R, L214F, M357T

 

33

K65R

-

G196R, L214F

 

41

K65R

-

S68G, P150S, E194K, G196R, I202V, L214F

 

65

K65R

K70N

S68G, A98G, Y115F

 

93

K65R

K70H

V8I, S68G, A98G, Y115F, K154E, A158P, I159L, G196R, L214F, D218E, K219R, H221P

 

115

K65R

K70H

V8I, K45Q, S68G, A98G, Y115F, V179I, G196R, L214F, K219R, K275R, R277K, M357T

30162

21 (Tx)

-

-

V75L, G196R, K275R

 

25

-

-

V75L, G196R, K275K/R

 

29

-

-

V75L, G196R, K275R

 

33

-

-

V75L, G196R, K275R

 

37

-

-

K22R, W88S, L214F

 

41

K65R

-

W88S, Y115F, E194K, L214F

 

65

K65R

-

S68S/N, W88S, Y115F

 

93

K65R

K70T

S68G, K70T, W88S, Y115F, K154E, A158P, L214F, K219Q

 

209

K65R

K70T

S68G, K70T, W88S, Y115F, T139A, I178M, L214F, H221Y, K275R, R277K, M357N

30478

21 (Tx)

-

-

V75L, H208L, L214F

 

25

-

-

V75V/L, H208L. L214F

 

29

-

K70E/K

H208L, L214F

 

33

K65K/R

K70E/Q/K

G196R, L214F

 

37

K65R

-

S68N, G196R, L214F

 

41

K65R

-

S68N, G196R, L214F

30338

21 (Tx)

-

-

G196R

 

22

-

-

V75L, G196R, L214F, K275R, M357T

 

23

-

-

V21I, V75L, G196R, L214F

 

25

-

K70K/E

V75L, G196R, L214F

 

29

K65R

-

G196R, L214F, M357T

 

33

K65R

-

G196R, L214F, K275R, M357T

 

41

K65R

-

S68N, Y115F, G196R, L214F

 

59

K65R

K70Q

S68N, Y115F

 

89

K65R

K70Q

K20R, Y115F, K154Q, A158T, I178M, E194K, G196R, L214F, K219Q

 

145

K65R

K70Q

V8I, K20R, M41L, S68G, W88S, Y115F, F116W, I178M, G196R, L214F, H221Y, K275R, R277K, P294Q, M357T

30339

21 (Tx)

-

-

E194K, G196R,

 

25

WT

-

W88S, G196R, L214F, M357T

 

29

K65R

-

W88S, G196R, K275R, R277K, M357T

 

33

K65R

-

S68R, W88S, G196R, L214F, K275R

 

41

K65R

-

S68K, W88S, G196R, R199M, K219E

 

59

K65R

-

S68K, W88S, Y115F, K219E

 

89

K65R

-

K22R, K64R, S68K, W88S, Y115F, K154Q, A158P, I178M, G196R

 

150

K65R

-

T39A, K45Q, K64R, S68K, W88S, Y115F, I178M, V195L, G196K, K219G, H221Y, K275R, R277K, M357T

30340

21 (Tx)

-

-

V75L, E194K, G196R,

 

22

-

-

V75L, G196R

 

23

-

K70K/E

G196R

 

25

-

K70K/E

G196R

 

29

K65R

-

G196R

 

33

K65R

-

G196R, L214F

 

41

K65R

-

S68G, Y115F, V118I, E194K, G196R, R199I

 

89

K65R

-

K20R, S68G, W88S, Y115F, G196R, R199I, L214F, H221Y

 

159

K65R

K70Q

S68K, W88S, Y115F, F116W, G196R, L214F, H221Y, S251N, R277K, M357T

30343

21 (Tx)

-

-

G196R, K219N

 

22

-

-

G196R, K219N, K275R, M357T

 

23

-

-

G196R, K275R, M357T

 

25

K65K/R

K70K/E

G196R, K275R, M357T

 

41

K65R

-

S68N, G196R

 

59

K65R

-

S68N, Y115F, Y181C, K219N/D

 

89

K65R

-

S68N, W88S, Y115F, F116W, G196R, K219H

 

150

K65R

K70H

M41L, S68K, W88S, Y115F, F116W, V118I, I178M, G196R, K219H, K275R, R277K, M357T

30576

20 (Tx)

-

-

V75I, E194K, G196R, L210V, L214F

 

21

-

-

V75L, G196R, L214F, K275R, G359S

 

22

-

K70E/K

G196R, L214F

 

24

-

K70E/K

G196R, E203G, L214F

 

28

-

K70E/K

G196R, L214F, M357T

 

32

K65R

 

S68N, G196R, L214F, K275R, M357T

 

36

K65R

 

S68N, G196R, L214F, M357T

 

40

K65R

-

S68N, I195T, G196R, L214F

 

53

K65R

-

S68N, Y115F

 

84

K65R

K70N

V8I, S68G, Y115F, F116W, Q145H, P150S, G196R, H208Q, L214F

 

178

K65R

K70H

V7I, K45Q, S68G, Y115F, F116W, R172S, K173Q, I178M, G196R, I202V, L214F, K219R, K275R, R277K, M357T

30577

20 (Tx)

-

-

E194K, G196R

 

22

-

-

V75L, G196R, L214F

 

24

-

K70E/K

I178M, G196R, L214F

 

28

K65K/R

K70E/K

I178M, G196R

 

40

K65R

-

K20R, S68N, E194K, G196R, R199K, L210V, L214F

 

47

K65R

-

S68N, G196R

 

265 (no CD8)

K65R

-

K20R, S68N, G196R, L214F, Q248N

 

296 (no Tx)

K65R

-

K20R, S68N, G196R, L214F, Q248N

30581

20 (Tx)

-

-

V75I, E194K, G196R,

 

22

-

-

V75L, G196R, L214L/F

 

24

-

K70K/E

V75L, G196R

 

28

-

K70E

G196R, M357T

 

32

K65R

-

G196R, L214F, M357T

 

40

K65R

-

S68G, G196R, L214F

 

53

K65R

K70T

S68G, F116W

 

84

K65R

K70T

S68G, A98G, F116W, P150S, I159V, R172I, V179G, Q222L

 

209

K65R

K70T

E40Q, K45Q, S68G, T69I, A98G, F116W, I178M, G196R, K219R, K275R, R277K, M357S

30842

20 (Tx)

-

-

V75L, E194K, G196R,

 

22

-

-

V75L, G196R, L214F

 

24

-

K70E

G196R, L214F

 

28

K65R/K

-

G196R, L214F

 

32

K65R

-

S68N, G196R, L214F, N218E, M357T

 

40

K65R

-

E194K, G196R, L214F

 

42

K65R

-

Y115F, Y181C, K219E

30845

20 (Tx)

-

-

V75I, E169K, E194K, G196R,

 

21

-

-

V75V/L, G196R

 

22

-

-

T69N/T, W88S, G196R, L214F

 

24

-

K70K/E

G196R, K275R

 

28

K65K/R

K70E

G196R

 

32

K65R

 

G196R, L214F, K275R, M357T

 

36

K65R

 

S68G, W88S, G196R, M357T

 

40

K65R

-

S68G, W88S, E194K, G196R, L214F

 

53

K65R

-

S68G, W88S, Y115F

 

84

K65R

K70N

S68G, W88S, A98G, Y115F, P150S, D177N

 

149

K65R

K70N

K11N, V21I, K22R, M41L, S68G, W88S, Y115F, F116W, V118I, H221Y, V245M, K275R, R277K, I275R, M357T

  1. All data were obtained from PBMC isolates by population sequencing methods. (Tx) indicates the start of tenofovir therapy. (no CD8) and (no Tx) indicate the viral rebound during CD8+ cell depletion experiment and tenofovir withdrawal experiment of animal 30577, respectively.
Back to article page

Retrovirology

ISSN: 1742-4690

Contact us