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Figure 5 | Retrovirology

Figure 5

From: Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection

Figure 5

Correlations of baseline viral and immunologic parameters and early virologic response to tenofovir therapy. Pre-treatment values of viral and immunologic parameters are baseline values at the onset of tenofovir treatment (i.e., ~20 weeks of infection). The early virologic response is expressed as fold decrease of viremia (viral RNA levels in plasma) after 1 week of tenofovir therapy. Spearman r and two-tailed p values are indicated for each graph. The pre-treatment viral RNA level correlated with the pre-treatment % CD4+ T lymphocytes (graph A), but did not correlate significantly with percentages of CD8+CD3+ T lymphocytes or CD20+ B lymphocytes (p = 0.40 and 0.12, respectively; data not shown). The early virologic response had significant correlations (p ≤ 0.05) with the pre-treatment viral RNA levels (graph B), % CD4+ T lymphocytes (graph C), and percentage and absolute counts of CD20+ B lymphocytes (data not shown). There was no correlation between the early virologic response to tenofovir and baseline lymphocyte counts, the percentages and absolute counts of CD3-CD8+ NK cells in peripheral blood, or SIV-specific IgG titers in plasma (data not shown).

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