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Figure 3 | Retrovirology

Figure 3

From: Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection

Figure 3

Individual data of plasma viral RNA levels and percentages of CD4+ T lymphocytes. Twelve RT-SHIV infected juvenile macaques were started on tenofovir treatment (10 mg/kg subcutaneously, once daily) at approximately 20 weeks of infection (vertical dotted line). Changes in tenofovir dosage regimens (in mg/kg) are indicated in the boxes along the X-axis. Viral RNA levels in plasma (in log-transformed copy number per ml plasma) are presented along the left Y-axis, while the % CD4+ T lymphocytes in peripheral blood is presented along the right Y-axis. The earliest detection of the K70E or K65R mutation in viral RNA in plasma virus by real-time RT-PCR is indicated (see Figure 6 for more details). Animals are arranged according to disease-free survival (which is indicated after each animal number). The presence or absence of the expression of the MHC I alleles Mamu-A*01 and Mamu-B*01 is indicated below each animal number.

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Retrovirology

ISSN: 1742-4690

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