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Figure 1 | Retrovirology

Figure 1

From: Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection

Figure 1

Serial in vivo passage of RT-SHIV: effect on virulence. A high dose of RT-SHIV (105 TCID50), propagated in vitro in CEMx174 cells, was inoculated intravenously in 3 animals (group A). Plasma collected 2 weeks later was pooled and administered intravenously to 4 animals (group B). The same procedure was repeated for the final passage into 5 animals (group C). There were no significant differences between the 3 groups with regard to viral RNA levels (calculated after log-transformation; graph A), mean absolute CD4+ T lymphocytes counts/μl and % CD4+ T lymphocytes in peripheral blood, (graphs B, C). Error bars indicate SEM.

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Retrovirology

ISSN: 1742-4690

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