Figure 5
Correlation between the inhibitory potency of different compounds on HIV-1 integrase strand transfer and in-silico fitness for a two-metal HIV-1 integrase core domain in complex with 5CITEP. x axis: the in-vitro inhibitory potency of the compounds is presented as a Log transform of the IC50 value retrieved from the NCBI database (Ref. [45]). y axis: the in-silico fitness is presented as a score automatically attributed by the GOLD program. The regression line best fitting the data points is shown as a solid line. Compounds are numbered as in Fig. 2.