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Table 3 Induction of P-gp expression in CEM and CEMrev cell lines exposed to IINs

From: HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein

Compound Concentration Days of culture % of P-gp expressing cells
    CEM CEMrev
None    0 1–3
RDS 1974 10 μg/ml 104 0 25–30
RDS 1983 25 μg/ml 28 0 7–10
RDS 1984 25 μg/ml 28 0 15–18
RDS 1996 10 μg/ml 28 0 17–20
Vinblastine 10 ng/ml 28 ND* 30–35
   104 ND* 60–70
  1. ND, not done
  2. * % of P-gp expressing cells could not be evaluated due to VBL toxicity. Prolonged and stepwise VBL treatment induced high percentage of P-gp expressing cells [31].