Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 2 Induction of functional conformation and drug transport inhibition exerted by other IINs in CEM MDR cells.

From: HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein

Compound Concentration μg/ml UIC2 epitope up-modulation (A) Doxorubicin efflux inhibition (B)
RDS 1992 25 NT +
  50 + ++
  100 ++ NT
RDS 1996 25 NT +
  50 NT ++
  100 NT NT
RDS 1997 25 NT +
  50 + ++
  100 ++ NT
RDS 2012 25 NT +
  50 + ++
  100 ++ NT
RDS 2022 25 NT +
  50 + ++
  100 ++ NT
  1. A, modulation of UIC2 epitope was studied in CEM-VBL10 cells; B, the effect of IINs on the doxorubicin transport inhibition was analysed in CEM-VBL100 cells; NT, not tested; the + or ++ symbols indicate arbitrary units in measuring and differentiating the level of UIC2 epitope modulation and doxorubicin retention.