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Figure 2 | Retrovirology

Figure 2

From: HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein

Figure 2

Drug transport inhibition mediated by IINs. Evaluation of efflux of the dye P-gp substrate doxorubicin in CEM-VBL100 MDR cells. Efflux was monitored in drug-free conditions (red histogram), in the presence of the potent P-gp blocker Verapamil (2.5 μg/ml) (blue histogram) or following incubation with several IINs (RDS1974, RDS1981, RDS1983 and RDS1984) (green histogram) at the indicated concentrations (range 1 μg/ml to 100 μg/ml).

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