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Figure 1 | Retrovirology

Figure 1

From: HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein

Figure 1

Functional conformation of P-gp induced by IINs. Fluorescence profile of mAb UIC2 staining on MDR CEM-VBL10 cells incubated in presence of the drug diluent (red histogram), 50 μg/ml of the indicated IINs (blue histogram), or the P-gp substrate vinblastine (10 μg/ml, VBL). MAb MM4.17 staining was carried out in identical conditions in MDR CEM-VBL10 cells incubated with drug diluent (red histogram) or 50 μg/ml of the RDS1974 (blue histogram).

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