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Figure 1 | Retrovirology

Figure 1

From: Impaired RNA incorporation and dimerization in live attenuated leader-variants of SIVmac239

Figure 1

Nucleotide position of deletion mutations within the leader sequence and the secondary structure of SIV mac239 leader RNA. A. Denotes the size and nucleotide position of deletion mutations located upstream (pU) or downstream (pD) of the major SD. All nucleotide deletions are relative to the transcriptional initiation site (1+) based on the sequence of the wild type clone of SIVmac239 [50]. B. Secondary structure was adapted from published information [13, 51]. All hairpin motifs are labeled according to their putative function and/or after comparable elements encoded by HIV-1/HIV-2 leader sequences. The following motifs are shown in bold type: the putative DIS palindrome at position +417-422, the splice donor (SD) at position +462, and the Gag initiation codon at position +533.

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