Skip to main content
Figure 6 | Retrovirology

Figure 6

From: Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus (JSRV) closely resembles lung cancer in sheep infected with JSRV

Figure 6

Hepatocellular tumors induced by intravenous injection of an AAV6 vector expressing JSRV Env. Panels A and B show low-magnification views of the same area of a liver stained with a mixture of the B3 and C9 Env Mab (light methyl green counterstain) (Panel A) or hematoxylin and eosin (Panel B). Panels C and D show a mixed tumor with adenomatous features in the upper right portion and adenocarcinomatous features in the lower left portion. Panel C shows staining with the Mab (hematoxylin counterstain) and Panel D shows staining with hematoxylin and eosin. Note the compression of liver tissue near the lower left side of the tumor. Panel E shows a high-magnification view of the same tumor in the panel above, with the division between adenoma and adenocarcinoma running from the top left to the bottom right of the panel. Note the linear staining between cells that likely represents Env in bile canaliculi. Panel F shows a tumor with a foamy appearance stained with the Env Mab (hematoxylin counterstain). Scale bars = 100 μm.

Back to article page