Figure 3
From: Kinetic studies of HIV-1 and HIV-2 envelope glycoprotein-mediated fusion
Time course for escape from HIV-2SBLEnv-mediated fusion inhibition. Fusion was measured as described in the legend to figure 1. Leu3A (3 μg/ml, triangles), AMD3100 (40 μM, circles) and SIV C34 (2 μM, squares) were added at different times following co-culture at 37°C and residual fusion was measured following their time of addition. The curves were fitted by the sigmoidal function given in the legend to figure 1; values of time for half maximal fusion (t1/2) are 26.9 ± 4.1, 24.8 ± 6.4 and 26.4 ± 2.3 minutes for Leu3A (green), AMD3100 (red) and C34 (blue), respectively.