Viral load of rhesus macaques vaccinated with Tat Oyi (panel A) and control macaques vaccinated with β-gal (panel B) following SHIV challenge (SHIV-BX08). The 965 (white square), 966 (no symbol), 969 (black circle), 975 (black square), 9611 (white circle), 9711 (white triangle) and 9712 (black triangle) macaques are the Tat Oyi vaccinated macaques. The 963 (white square), 964 (black square), 978 (white circle) and 9610 (black circle) Macaques are the controls vaccinated with β-gal. Two vaccinated macaques (965 and 969) on five had a viremia up to or superior to 1 millions RNA copies/ml that similar to controls. Macaque 966 had a viremia almost undetectable after the first SHIV challenge and remained at the same level in spite of a second challenge with SHIV 162P 3.2 seven weeks after the first challenge. The other macaques were not challenged twice. Control macaque 963 had an unexpected low viremia. Panel C: Grey bars indicate the post infection viremia in the plasma at two weeks and the black bars indicate viremia at nine weeks post-infection of the challenged macaques. Macaque 966 has a higher viremia at nine weeks due to its second SHIV challenge.