The conserved dileucine- and tyrosine-based motifs in MLV and MPMV envelope glycoproteins are both important to regulate a common Env intracellular trafficking

Table 1 Summary of the roles of the motifs in MLV and MPMV Env CT in subcellular Env trafficking.

MOTIF (MLV/MPMV)	ROLE IN TRAFFICKING	EFFECT OF MUTATION
²³YHQL²⁶/²³YHRL²⁶	Endocytosis	Increase plasma membrane localization
²³YHQL²⁶/²³YHRL²⁶	TGN retrieval	Delocalization in unidentified late-endocytic compartments
³LV⁴/³LM⁴	Sorting from TGN	Delocalization in the endosomal pathway

ISSN: 1742-4690