Table 1 Effect of various viral proteins on centrosomal abnormalities
Viral Protein | Cellular Interacting Protein | Function in Normal Cells | Phenotype |
|---|---|---|---|
HBV X | Crm1 | Nuclear export receptor | Abnormal centrioles >2 centrosomes per cell |
HPV E7 | Rb | Tumor suppressor Transcriptional repressor | >2 centrosomes per cell |
HPV E6 | P53 | Tumor suppressor | >2 centrosomes per cell |
KSHV LANA | P53 | Tumor suppressor | Abnormal mitotic spindles >2 centrosomes per cell |
HTLV Tax | TaxBP181 | Mitotic spindle checkpoint protein | Multinucleated cells |
| Â | RanBP1 | Regulator of Ran-GTPase pathway | >2 centrosomes per cell |
| Â | Tax1BP2 | Regulates centrosome duplication | >2 centrosomes per cell |