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Figure 5 | Retrovirology

Figure 5

From: Candidate polyanion microbicides inhibit HIV-1 infection and dissemination pathways in human cervical explants

Figure 5

Stimulation of inflammatory cytokines in cervical tissue treated with polyanions. Tissue explants were exposed to PRO 2000 (■), Dextrin Sulphate (□) or Nonoxynol-9 () for 2 hours prior to compound removal by washing and overnight culture in the absence of compound. Culture supernatants were assessed (using the Bioluminex assay) for the presence of the cytokines: A) IL-1β; B) TNF-α; and C) RANTES. Data represent the mean ± SEM for 3 individual donors. Statistical analysis was completed using student's T-test with statistically significant changes marked *** (p < 0.005). ND = Not determined. Toxic = Compound treatment caused >50% reduction in tissue viability.

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