Table 2 Tax activated genes involved in aneuploidy

D87898

Arf1

ADP-ribosylation factor 1

Membrane vesicle formation, inactivation nec. for mitotic Golgi breakdown, chromosome segregation, and cytokinesis [95–97]

BC054097

Cetn3

centrin 3

spindle cell body duplication need for bipolarity in cytokinesis [98–103]

AF016583

Chek1

checkpoint kinase 1 homolog (S. pombe)

needed for S and G2 checkpoints after DNA damage; Tax has been shown to disrupt its function [24,25,104–106]

AF098508

Dctn3

dynactin 3

light-chain subunit of dynactin complex (p24); dynactin complex involved in vesicle movement; dynactin complex interacts with NuMA and dynein in order to tether microtubules at the spindle poles and that are essential for mitotic spindle pole assembly and stabilization; recruitment by ZW10 protein to the kinetichore [107–110]

NM_009503

p97(Vcp)

valosin containing protein

aka cdc48; needed for spindle disassembly after segregation; Golgi disassembly-assembly [111–113]

BC046832

Ppp1cb

protein phosphatase 1, catalytic subunit, beta isoform

antagonist of Aurora B kinase during mitosis, i.e. regulating the protein interface between the centromeres and the mitotic spindle; possible downstream targets include kinetochore protein Ndc10, CENP-A, which substitutes for histone H3 in centromeric nucleosomes, and inner centromere protein INCENP; mutation of PP1 or inactivation was shown to result in cytokinesis defects. [114]

NM_008989

Pura

purine rich element binding protein A

involved in DNA replication and transcription; overexpression results in G2 blockage [115,116]

AJ534939

Smc2l1

SMC2 structural maintenance of chromosomes 2-like 1 (yeast)

aka CAP-E protein, that is part of the condensin protein complex originally identified in Xenopus; protein complex is needed for chromosome condensation; CAP-E has been found to interact with DNA ligase IV (DNA double-strand break repair protein) possible interaction important for genome stability [117–120]

BC009167

Sugt1

SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)

recent study shows that SGT1 is needed for kinetechore assembly [66,76]

AF077002

Ywhah

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide

binds to CDC25B in a phosphorylation independent mechanism [121,122]

BC027100

Zwint-1

ZW10 interactor

specifies the kinetochore association of ZW10 which may act as part of, or immediately downstream of, the wait anaphase tension-sensing checkpoint [123,124]