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Table 2 Tax activated genes involved in aneuploidy

From: Involvement of HTLV-I Tax and CREB in aneuploidy: a bioinformatics approach

Genbank Accession Number Gene   Fold change Function
D87898 Arf1 ADP-ribosylation factor 1 2.6 Membrane vesicle formation, inactivation nec. for mitotic Golgi breakdown, chromosome segregation, and cytokinesis [95–97]
BC054097 Cetn3 centrin 3 2.2 spindle cell body duplication need for bipolarity in cytokinesis [98–103]
AF016583 Chek1 checkpoint kinase 1 homolog (S. pombe) 2.3 needed for S and G2 checkpoints after DNA damage; Tax has been shown to disrupt its function [24,25,104–106]
AF098508 Dctn3 dynactin 3 2.4 light-chain subunit of dynactin complex (p24); dynactin complex involved in vesicle movement; dynactin complex interacts with NuMA and dynein in order to tether microtubules at the spindle poles and that are essential for mitotic spindle pole assembly and stabilization; recruitment by ZW10 protein to the kinetichore [107–110]
NM_009503 p97(Vcp) valosin containing protein 3.0 aka cdc48; needed for spindle disassembly after segregation; Golgi disassembly-assembly [111–113]
BC046832 Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 2.5 antagonist of Aurora B kinase during mitosis, i.e. regulating the protein interface between the centromeres and the mitotic spindle; possible downstream targets include kinetochore protein Ndc10, CENP-A, which substitutes for histone H3 in centromeric nucleosomes, and inner centromere protein INCENP; mutation of PP1 or inactivation was shown to result in cytokinesis defects. [114]
NM_008989 Pura purine rich element binding protein A 2.4 involved in DNA replication and transcription; overexpression results in G2 blockage [115,116]
AJ534939 Smc2l1 SMC2 structural maintenance of chromosomes 2-like 1 (yeast) 2.8 aka CAP-E protein, that is part of the condensin protein complex originally identified in Xenopus; protein complex is needed for chromosome condensation; CAP-E has been found to interact with DNA ligase IV (DNA double-strand break repair protein) possible interaction important for genome stability [117–120]
BC009167 Sugt1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) 2.3 recent study shows that SGT1 is needed for kinetechore assembly [66,76]
AF077002 Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 2.0 binds to CDC25B in a phosphorylation independent mechanism [121,122]
BC027100 Zwint-1 ZW10 interactor 2.1 specifies the kinetochore association of ZW10 which may act as part of, or immediately downstream of, the wait anaphase tension-sensing checkpoint [123,124]