Table 1 Virus characteristics. Virus and patient characteristics of primary HIV-1 isolates obtained from Cameroon. Subtyping was based on complete pol and complete env, gag p24, gag p17, tat, rev, nef, and vpu nucleotide sequences. CD4+ T cell counts and viral load were determined at the time of virus isolation. Co-receptor usage was tested on U87.CD4 cells expressing either CCR5 or CXCR4.
Virus Isolate | Subtype | Year of isolation | Country | CD4+ T cell count9 | Viral load10 | Co-receptor tropism | |||
|---|---|---|---|---|---|---|---|---|---|
| Ā | env 1 | pol 2 | gag 3 | other4 | Ā | Ā | Ā | Ā | Ā |
MP569 | AG | AG | AG5 | - | 1997 | CM | 1029 | 2.95 | R5 |
MP538 | AG | AG | AG5 | - | 1996 | CM | 350 | 4.49 | R5 |
MP573 | AG | AG | AG5 | - | 1997 | CM | 277 | 5.67 | R5 |
MP568 | AG | AG | AG5 | - | 1997 | CM | 266 | 4.91 | R5 |
MP570 | AG | AG | AG5 | - | 1997 | CM | 213 | 5.41 | R5 |
| Ā | Ā | Ā | Ā | Ā | Ā | Average | 427 | 4.69 | Ā |
MP642 | AG | AG | AG | AG7 | 1997 | CM | 104 | 5.71 | R5 |
MP578 | AG | AG | AG | AG7 | 1997 | CM | 8 | 5.41 | R5X4 |
MP581 | AG | AG | AG5 | - | 1997 | CM | 8 | 5.80 | X4 |
MP522 | AG | AG | AG5 | - | 1996 | CM | 2 | 5.10 | X4 |
MP1378 | AG | AG | AG5 | AG8 | 1999 | CM | 0 | 5.89 | R5 |
| Ā | Ā | Ā | Ā | Ā | Ā | Average | 24 | 5.58 | Ā |
MP801 | G | G | G6 | G8 | 1997 | CM | 731 | 3.85 | R5 |
MP582 | A | A | A5 | A7 | 1997 | CM | 521 | 3.78 | R5 |
MP1370 | A | A | - | - | 1999 | CM | 477 | 4.31 | R5 |
MP1033 | G | G | G6 | G8 | 1998 | CM | 394 | 2.39 | R5 |
MP1416 | G | G | G | G7 | 1999 | CM | 368 | 5.59 | R5 |
MP1433 | A | A | - | - | 1999 | CM | 321 | 4.93 | R5 |
MP812 | A | A | A5 | A8 | 1997 | CM | 310 | 4.52 | X4 |
| Ā | Ā | Ā | Ā | Ā | Ā | Average | 446 | 4.20 | Ā |
MP1411 | A | A | - | - | 1999 | CM | 105 | 5.18 | R5 |
MP1287 | G | G | - | - | 1999 | CM | 91 | 5.83 | R5 |
MP1416 | G | G | G | G7 | 1999 | CM | 23 | 5.38 | R5X4 |
| Ā | Ā | Ā | Ā | Ā | Ā | Average | 73 | 5.46 | Ā |