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Table 3 Differentially Expressed Genes Between Mock- and FrCasE-infected Microglia

From: Gene expression profiling of microglia infected by a highly neurovirulent murine leukemia virus: implications for neuropathogenesis

     Mock-infected FrCasE-infected  
probe set gene Accession Function/processa mean SE Callb mean SE Callb fold change
1425923_at *neuroblastoma myc-related oncogene 1 M36277 Transcription/cell cycle control 6.96 27.32 A 2239.4 116.8 mP 321.9
1425131_at *protein tyrosine phosphatase, non-receptor type 5 U28216 Tyrosine phosphatase -101.71 12.11 A 235.6 48.34 A 235.6
1431214_at *RIKEN cDNA 1300007C21 gene (vaginal cDNA) BG297038 Retrovirus-related POL polyprotein -14.82 11.41 A 146.69 79.6 mP 146.69
1456182_x_at *melanoma antigen BB795191 Viral envelope related 39.08 9.27 A 939.13 74.66 A 24.03
1431213_a_at *RIKEN cDNA 1300007C21 gene(vaginal cDNA) BG297038 Retrovirus-related POL polyprotein 43.54 12.85 P 571.78 257.8 P 13.13
1427694_at *gonadotropin releasing hormone receptor L28756 G-protein coupled receptor 26.1 6.83 A 218.05 14.59 A 8.35
1422720_at *ISL1 transcription factor, LIM/homeodomain, (islet-1) NM_021459 Transcription factor/development 28.05 13.62 A 215.44 14.84 A 7.68
1429212_a_at *RIKEN cDNA 1700008D07 gene (testis cDNA) AK005758 Inflammatory response 27.15 6.67 A 187.81 39.86 A 6.92
1455788_x_at *Polymerase (DNA-directed), delta interacting protein 3 BB495487 Nucleic acid binding 168.36 116.7 P 919.68 61.16 P 5.46
1452288_at *expressed sequence BB128963 (neonatal cerebellum) BG071933 Similar to myotubularin related proteins 64.79 36.28 mA 352.56 23.76 mA 5.44
1449163_at single Ig IL-1 receptor related protein NM_023059 Immune reponse inhibition 75.17 22.22 mA 405.05 69.42 mP 5.39
1425260_at albumin 1 BC024643 Carrier protein 32.31 11.17 A 136.36 15.27 A 4.22
1450610_at *urocortin NM_021290 Neuropeptide signaling 66.48 25.27 A 208.42 18.38 A 3.13
1450824_at *patched homolog NM_008957 Hedgehog receptor 82.11 17.51 A 245.79 33.45 A 2.99
1437712_x_at exosome component 4 AV212315 exonuclease/RNA processing 347.13 128.5 A 988.22 288.1 A 2.85
1451107_at *TBC1 domain family, member 22a BC023106 GTPase activator 296.8 27.95 mA 605.2 52.13 mA 2.04
1460469_at *tumor necrosis factor receptor superfamily, member 9 BM250782 Receptor/defense response 148.29 28.95 A 297.71 36.4 mA 2.01
1451382_at RIKEN cDNA 1810008K03 gene, ChaC 1 BC025169 ChaC, cation transport regulator-like 209.65 14.12 mP 35.33 54.81 mA -5.93
  1. *Genes with asterisks are those that showed differential expression in both Fr57E- and FrCasE-infected microglia when compared to mock-infected microglia (see table 2).
  2. Bolded italicizedgenes are those that show differential expression only in FrCasE-infected microglia compared to mock-infected microglia.
  3. a- Function/process was determined by gene ontology information provided through the Affymetrix NetAffx Analysis Center and its links to PubMed, EMBL, etc.
  4. b-A = Absent call in 5/5 arrays; mA = Absent calls in 3–4/5 arrays; P = Present call in 5/5 arrays; mP = present calls in 3–4/5 arrays. Call determined by Microarray suite 5.0 (Affymetrix) SE-Standard Error.