Skip to main content

Table 3 Differentially Expressed Genes Between Mock- and FrCasE-infected Microglia

From: Gene expression profiling of microglia infected by a highly neurovirulent murine leukemia virus: implications for neuropathogenesis

    

Mock-infected

FrCasE-infected

 

probe set

gene

Accession

Function/processa

mean

SE

Callb

mean

SE

Callb

fold change

1425923_at

*neuroblastoma myc-related oncogene 1

M36277

Transcription/cell cycle control

6.96

27.32

A

2239.4

116.8

mP

321.9

1425131_at

*protein tyrosine phosphatase, non-receptor type 5

U28216

Tyrosine phosphatase

-101.71

12.11

A

235.6

48.34

A

235.6

1431214_at

*RIKEN cDNA 1300007C21 gene (vaginal cDNA)

BG297038

Retrovirus-related POL polyprotein

-14.82

11.41

A

146.69

79.6

mP

146.69

1456182_x_at

*melanoma antigen

BB795191

Viral envelope related

39.08

9.27

A

939.13

74.66

A

24.03

1431213_a_at

*RIKEN cDNA 1300007C21 gene(vaginal cDNA)

BG297038

Retrovirus-related POL polyprotein

43.54

12.85

P

571.78

257.8

P

13.13

1427694_at

*gonadotropin releasing hormone receptor

L28756

G-protein coupled receptor

26.1

6.83

A

218.05

14.59

A

8.35

1422720_at

*ISL1 transcription factor, LIM/homeodomain, (islet-1)

NM_021459

Transcription factor/development

28.05

13.62

A

215.44

14.84

A

7.68

1429212_a_at

*RIKEN cDNA 1700008D07 gene (testis cDNA)

AK005758

Inflammatory response

27.15

6.67

A

187.81

39.86

A

6.92

1455788_x_at

*Polymerase (DNA-directed), delta interacting protein 3

BB495487

Nucleic acid binding

168.36

116.7

P

919.68

61.16

P

5.46

1452288_at

*expressed sequence BB128963 (neonatal cerebellum)

BG071933

Similar to myotubularin related proteins

64.79

36.28

mA

352.56

23.76

mA

5.44

1449163_at

single Ig IL-1 receptor related protein

NM_023059

Immune reponse inhibition

75.17

22.22

mA

405.05

69.42

mP

5.39

1425260_at

albumin 1

BC024643

Carrier protein

32.31

11.17

A

136.36

15.27

A

4.22

1450610_at

*urocortin

NM_021290

Neuropeptide signaling

66.48

25.27

A

208.42

18.38

A

3.13

1450824_at

*patched homolog

NM_008957

Hedgehog receptor

82.11

17.51

A

245.79

33.45

A

2.99

1437712_x_at

exosome component 4

AV212315

exonuclease/RNA processing

347.13

128.5

A

988.22

288.1

A

2.85

1451107_at

*TBC1 domain family, member 22a

BC023106

GTPase activator

296.8

27.95

mA

605.2

52.13

mA

2.04

1460469_at

*tumor necrosis factor receptor superfamily, member 9

BM250782

Receptor/defense response

148.29

28.95

A

297.71

36.4

mA

2.01

1451382_at

RIKEN cDNA 1810008K03 gene, ChaC 1

BC025169

ChaC, cation transport regulator-like

209.65

14.12

mP

35.33

54.81

mA

-5.93

  1. *Genes with asterisks are those that showed differential expression in both Fr57E- and FrCasE-infected microglia when compared to mock-infected microglia (see table 2).
  2. Bolded italicizedgenes are those that show differential expression only in FrCasE-infected microglia compared to mock-infected microglia.
  3. a- Function/process was determined by gene ontology information provided through the Affymetrix NetAffx Analysis Center and its links to PubMed, EMBL, etc.
  4. b-A = Absent call in 5/5 arrays; mA = Absent calls in 3–4/5 arrays; P = Present call in 5/5 arrays; mP = present calls in 3–4/5 arrays. Call determined by Microarray suite 5.0 (Affymetrix) SE-Standard Error.
Back to article page

Retrovirology

ISSN: 1742-4690

Contact us