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Figure 6 | Retrovirology

Figure 6

From: Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells

Figure 6

Effects of AG490 on the expression of anti-apoptotic proteins. (A) HTLV-1-infected T-cell lines were treated with increasing concentrations of AG490 for 24 h. Amounts of c-IAP-2, XIAP, survivin, Bcl-2, Bcl-xL and Tax were determined by Western blot analysis. (B) Primary ATL cells were treated with (+) or without (-) 50 μM AG490 for 24 h. The expression of c-IAP2, XIAP, survivin and Tax was assessed by Western blot analysis. (C) HUT-102 cells were treated with (+) or without (-) 50 μM AG490 for 24 h. The expression of HTLV-1 viral proteins, envelope glycoprotein gp46 and p19 core protein was assessed by Western blot analysis. The amount of actin is shown as a loading control.

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