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Figure 5 | Retrovirology

Figure 5

From: Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells

Figure 5

Effects of AG490 on the expression of cell-cycle associated proteins. HTLV-1-infected T-cell lines were treated with increasing concentrations of AG490 for 24 h. Amounts of cyclin D1, cyclin D2, Cdk4, Cdk6, p53, p21, Pim-1 and c-Myc were determined by Western blot analysis. (B) Primary ATL cells were treated with (+) or without (-) 50 μM AG490 for 24 h. The expression of cyclin D2 and p53 was assessed by Western blot analysis. The amount of actin is shown as a loading control.

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