Molecular characterization of the HIV-1 gagnucleocapsid gene associated with vertical transmission

Retrovirology

Table 1 Patient demographics, clinical, and laboratory parameters of six HIV-1 infected mother-infant pairs involved in vertical transmission.

Patient	Age	Sex	CD4+ cells/mm3	Length of infection	Antiviral Drug	Clinical Evaluation
MB	28 yr	F	509	11 mo	None	Asymptomatic
IB	4.75 mo	M	1942	4.75 mo	None	Asymptomatic
MC	23 yr	F	818	1 yr 6 mo	None	Asymptomatic
IC	14 mo	F	772	14 mo	ZDV	Symptomatic AIDS
MD	31 yr	F	480	2 yr 6 mo	None	Asymptomatic
ID	28 mo	M	46	28 mo	ddC	Symptomatic AIDS; failed ZDV therapy
ME	26 yr	F	395	2 yr	ZDV	Symptomatic AIDS
IE	34 mo	M	588	34 mo	ZDV	Symptomatic AIDS
MF	23 yr	F	692	2 yr 10 mo	None	Asymptomatic
IF	1 wk	M	2953	1 wk	ZDV	Asymptomatic
MH	33 yr	F	538	5 mo	None	Asymptomatic
IH1	7 mo	F	3157	7 mo	ACTG152	Hepatosplenomegaly, lymphadenopathy
IH2	7 mo	F	2176	7 mo	ACTG152	Hepatosplenomegaly, lymphadenopathy

M: Mother; I: Infant
Length of infection: The closest time of infection that could be documented was the first positive HIV-1 serology date or the first visit of the patient to the AIDS treatment center, where all the HIV-1 positive patients were referred to as soon as an HIV-1 test was positive. As a result, these dates may not reflect the exact dates of infection.
Clinical evaluation for the infants is based on CDC criteria [70]
Mother and infant samples for each pair were collected at the same time

ISSN: 1742-4690