Figure 3

Location of mutations found in Tax 2A proteins. (A) Schematic representation of functional domains in Tax 2A Mo. These regions include CREB binding domains at the amino and carboxy termini, domains important in CREB and NFkB activation flanking a domain found to be important in NFkB activation [19], a domain involved in the cytoplasmic localisation of Tax 2 proteins [22], a nuclear localisation domain (NLS) [16] and a nuclear export signal (NES) [18]. Mutations which give rise to the loss of activation of CREB alone, NFkB alone or CREB and NFkB pathways by Mo are indicated. (b) Relative position of amino acid changes found in Lor and Gar.