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Table 1 IC50 values of Rgp41A and Rgp41B on the entry of pseudotyped or laboratory-adapted HIV-1 isolates into HeLa-CD4-LTR-LacZ cells.

From: Antiviral properties of two trimeric recombinant gp41 proteins

  

Rgp41A

Rgp41B

T-20

  

μg/ml

nM

μg/ml

nM

μg/ml

nM

Pseudotyped

LAI

2.5a

56

18

429

/

/

 

ADA

7

156

NE

NE

/

/

Laboratory-adapted

LAI

13

289

42*

1000

0.05

11

 

NDK

38*

844

70*

1667

0.04

9

 

YU2

22

489

NE

NE

2

444

 

ADA

NEb

NE

NE

NE

1.75

389

  1. aThese values correspond to the amount of recombinant proteins resulting in a 50% decrease in reporter activity compared to the value in the absence of inhibitor. Luciferase and β-Galactosidase were used as reporters of infection in the case of pseudotyped viruses and laboratory-adapted strains, respectively. This table shows the averages of a typical experiment performed in duplicate. *: Estimated from exponential regression analysis. bNE:No effect.