From: Coordinate enhancement of transgene transcription and translation in a lentiviral vector
 | RNA copy number (× 103)a |  |  | |||
---|---|---|---|---|---|---|
 | Nucleoplasm | Cytoplasm | Cytoplasmic accumulationb | Translational efficiencyc | ||
Vector | luc | actin | luc | actin | Â | Â |
U3-Luc | 56.7 ± 5.4 (1) | 59.3 | 25.3 ± 2.8 (1) | 375 | 0.45 | 1 |
PCE-Luc | 34.9 ± 3.8 (0.47) | 76.6 | 5.4 ± 0.2 (0.2) | 372 | 0.16 | 5 |
IE-U3-Luc | 91.3 ± 1.5 (1) | 69.1 | 46.8 ± 12.9 (1) | 417 | 0.51 | 0.5 |
IE-PCE-Luc | 96.8 ± 2.7 (0.88) | 82.5 | 18.3 ± 2.7 (0.4) | 384 | 0.19 | 3 |