Figure 4From: A balanced transcription between telomerase and the telomeric DNA-binding proteins TRF1, TRF2 and Pot1 in resting, activated, HTLV-1-transformed and Tax-expressing human T lymphocytesA model for hTERT and shelterin gene expression in T lymphocytes. In the upper panel, CD4+ T lymphocytes were either resting or activated with a cocktail of anti CD3/anti CD28 antibodies. In the lower panel, three types of Tax-expressing T lymphocytes were represented. The model is based on the telomeric transcriptional profile defined as a balance between hTERT on one hand, and shelterin (POT1, TERF1 and TERF2) gene expression on the other hand.Back to article page