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Figure 5 | Retrovirology

Figure 5

From: Amino acid residues that are important for Hyal2 function as a receptor for jaagsiekte sheep retrovirus

Figure 5

Amino acid alignment of human Hyal2, C3H mouse Hyal2, and bee venom Hya. Proteins were aligned by using ClustalW [23]. The sequence of the mature protein is shown for Hya [10], while amino acids 1 – 377 of the precursor forms of the Hyal2 proteins are shown. Amino acid residues colored red indicate the positions at which alteration of human to mouse Hyal2 amino acids have the largest effects on the receptor activity of human Hyal2. White letters indicate amino acids shared between at least two sequences, and black or red letters indicate unique amino acids at a given position. Amino acid identity (*), strong similarity (:), weaker similarity (.), and dissimilarity (no mark) are indicated below the sequences, numbers above the sequences refer to amino acid position in the Hyal2 sequences, and dots indicate 10 base-pair intervals in the Hyal2 sequences. Downward arrows indicate positions of junctions in the chimeric human/mouse Hyal2 chimeras.

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