Figure 2

Schematic of Fv4 mediated interference of MuLV infection. Fv4 expression results in sustained levels of Fv4 Env proteins in the cytoplasm. Binding of the mCAT1 receptor by Fv4 Env proteins, either in the cytoplasm or at the cell surface (the exact location of interaction is unresolved, which is represented by question marks), prevents MuLV Env to interact with mCAT1, as either the receptor is already occupied by Fv4, or it cannot reach the cell surface when bound to Fv4 in the cytoplasm.