HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain

Retrovirology

Table 1 The relative activity of Rev and M4 mutants

	pDM138-RRE Rev activity as CAT produced (%)	pDM138-6xIIB Rev activity as CAT produced (%)
Rev (positive control)	100	100
Rev-3xNLS	81	113
M4	7	0
M4-3xNLS	10	24
NOS-M4	67	72
M4-M4	73	61
Tat (negative control)	0	0

The numbers represent the mean value of three or more independent experiments related to the activity of wild type Rev, the negative control and the amount of cellular protein.

ISSN: 1742-4690