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Table 1 The relative activity of Rev and M4 mutants

From: HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain

  pDM138-RRE Rev activity as CAT produced (%) pDM138-6xIIB Rev activity as CAT produced (%)
Rev (positive control) 100 100
Rev-3xNLS 81 113
M4 7 0
M4-3xNLS 10 24
NOS-M4 67 72
M4-M4 73 61
Tat (negative control) 0 0
  1. The numbers represent the mean value of three or more independent experiments related to the activity of wild type Rev, the negative control and the amount of cellular protein.