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Table 2 Distribution of proviral load in PBMC and organs of HTLV-I infected rabbits*

From: Quantification of HTLV-I proviral load in experimentally infected rabbits

  Inoculated with
  Naked DNA Cell-free virus Whole blood
ID (Mo.) BH19(30) BH21(30) BH25(30) T4-9(11) BH69(19) BH76(17) BH89 (18)
PBMC 7.5 3.9 1.4 6.7 1.3 2.2 8.7
Thymus 22.6 0.4 0.6 0.1 0.3 0.5 1.0
Liver 1.3 0.3 0.3 0.3 0.4 1.8 0.8
Spleen 1.6 0.4 0.1 0.3 0.3 1.7 ND
Skin 23.0 0.3 0.2 4.1 0.2 2.3 0.5
Heart 12.7 2.5 0.3 12.0 0.3 3.1 1.9
Lung 1.8 0.8 0.8 ND 0.7 1.5 2.0
Kidney 3.4 0.5 1.6 0.2 0.5 0.9 1.4
Uterus 3.2 3.0 0.3 ND 1.2 5.0 0.5
Spinal cord 1.7 0.2 0.9 50.5 0.4 0.3 1.2
Brain 0.1 0.3 ND 6.9 ND ND ND
Tumor NA NA 1.8 1.9 NA 11.0 NA
  1. * Proviral load was reported as copy number per ng of genomic DNA. ND, not determined.
  2. Rabbit identification number (month post inoculation).
  3. Rabbits T4-9 had a uterine leiomyoma, BH76 had benign endometrial dysplasia, and BH25 developed a uterine adenocarcinoma. NA, not applicable.