Figure 4From: Intracellular immunity to HIV-1: newly defined retroviral battles inside infected cellsSchematic representations of hTRIM5α, macTRIM5α, and omTRIM5a. CypA proteins. hTRIM5α contains 493 residues and four conserved motifs, whose positions are given. They are the RING domain, B box, coiled-coil and SPRY domains. The latter domain is required for species-specific restriction of primate lentiviruses and is diagrammed in red. A key residue in this domain, which is the arginine at position 332 in hTRIM5α, or the proline at position 334 in macTRIM5α, is responsible for its species-specific inhibition of lentiviral replication. omTRIM5α from owl monkeys contains an N-terminal omTRIM5α sequence to position 299, linked in-frame to the entire CypA gene (147 residues)(omTRIM5α.CypA).Back to article page