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Figure 4 | Retrovirology

Figure 4

From: The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions

Figure 4

The phosphorylation of Gag at Ser487 facilitates the interaction of Vpr and Gag-p6. (A) Schematic representation of the HIV-1 Gag-p6 sequence indicating the binding motifs, Tsg101, Alix and Vpr, located around the Ser487 site. (B) Complex structure models of Gag-p6 with Alix or Vpr. The structural calculations were undertaken using MOE. Upper panel shows structural models of the interaction of Alix with wild-type Gag-p6, Gag-p6Ser487A or phosphorylated Gag-p6-Ser487. Bottom panel shows structural models of the interaction of Vpr with wild-type Gag-p6, Gag-p6Ser487A or phosphorylated Gag-p6-Ser487. Binding energies of p6 with Alix or Vpr calculated from the structural models were shown in the bottom tables, where the highly negative value indicates the stable binding.

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