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Table 2 Percent neutralization of different virus strains by SHIVIG in TZM-bl cell-based assay

From: Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose

Virus Clade Tier SHIVIG bPositive control
KNH1088.ec5 A 2 0 83
SF162 PV B 1 94 100
BaL.ec1 B 1 92 99
GS015.ec12 C 1 74 95
GS 014 IMC C 2 0 82
E0836M4.ec3 D 2 0 80
CM235.ec5 AE 2 66 100
GS 020 IMC AE 2 0 38
55815.ec3 AG 2 0 75
SHIV-2873Nip C 2 a58 c56
  1. SHIVIG was tested at 0.5 mg/ml, except where noted. aNeutralization obtained with 1 mg/ml of SHIVIG. bAn HIV-positive serum pool was used as positive control, except as indicated. cBnmAb VRC01 (50 μg/ml) was used as positive control. IMC, infectious molecular clone. All neutralization assays were performed at least in duplicate.