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Table 2 Effects of the M50I and R263K mutations on IC 50 s for DTG, RAL, and EVG

From: The M50I polymorphic substitution in association with the R263K mutation in HIV-1 subtype B integrase increases drug resistance but does not restore viral replicative fitness

  

DTG

RAL

EVG

Backbone

Genotype

IC50 (nM)

FC

IC50 (nM)

FC

IC50 (nM)

FC

pNL4.3

WT

0.3113

-

0.1023

-

1.082

-

 

M50I

0.6053

1.94

0.04851

0.47

5.9

5.45

 

R263K

2.662

8.55

0.1898

1.85

23.16

21.4

 

M50I/R263K

4.854

15.59

0.3643

3.56

37.26

34.44

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Retrovirology

ISSN: 1742-4690

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