Table 1 Effects of the M50I and R263K mutations on DTG, RAL, and EVG inhibitory constants ( K i )
DTG | RAL | EVG | ||||
|---|---|---|---|---|---|---|
INB | Relative | Fold | Relative | Fold | Relative | Fold |
V max | Change (Ki) | V max | Change (Ki) | V max | Change (Ki) | |
WT | 100 | 1 | 100 | 1 | 100 | 1 |
M50I | 109 | 2.085 | 118 | 2.467 | 108 | 2.2 |
R263K | 105 | 2.627 | 106 | 5.404 | 117 | 6.4 |
M50I/R263K | 108 | 2.824 | 95 | 4.255 | 120 | 3 |