Figure 4From: The M50I polymorphic substitution in association with the R263K mutation in HIV-1 subtype B integrase increases drug resistance but does not restore viral replicative fitnessM50I does not compensate for the reduction in HIV replication associated with R263K. Effects of the M50I and R263K mutations on HIV infectivity in TZM-bl cells (A) and replication capacity in PM1 cells (B).Back to article page