Figure 4
From: Microarray analysis reveals global modulation of endogenous retroelement transcription by microbes
RE expression in the gut is dependent on genotype and husbandry conditions. (A) Heatmap of RE-reporting probes significantly regulated between GF and SPF housing conditions (p < 0.01 by ANOVA comparing husbandry conditions, eliminating genotype and tissue), using data from E-GEOD-17438, a Mouse Gene 1.0ST array. Each column is a single tissue from a single mouse. Intestinal tissues are separated with vertical lines in anatomical order: duodenum, jejunum, ileum and colon. Probes reporting MMTV, MLV, and Emv2 expression are highlighted. (B) qRT-PCR analysis of eMLV expression between Myd88-deficient and -sufficient B6 mice housed in SPF or GF facilities. Values exceeding 103 are considered high and are colored red.