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Figure 4 | Retrovirology

Figure 4

From: A CD4+T cell antagonist epitope down-regulates activating signaling proteins, up-regulates inhibitory signaling proteins and abrogates HIV-specific T cell function

Figure 4

Genes with 1.5 fold or greater difference in expression between Ag and Ag + Ant. Fold change was calculated and Ag + Ant was subtracted from Ag treatment. Data were then sorted from highest to lowest and 1.5 fold or greater differences. Replicate values for up-regulated and down-regulated genes are displayed in a heat map (A). Expression of up-regulated (B) and down-regulated (C) genes with medians from individual treatments are shown (Unstim = Unstimulated, Ag = Agonist, Ag + Ant = Agonist + Antagonist, Ant = Antagonist alone). p-Values were determined by Kruskal-Wallis followed by Dunn’s Multiple Comparisons Test, *** = p < 0.001.

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