Cell activation and HIV-1 replication in unstimulated CD4+T lymphocytes ingesting exosomes from cells expressing defective HIV-1

Table 1 Proteome of F12/HIV-1 ^a

Viral gene	Amino acid substitutions	Viral protein product
*gag*	p17: 1	Inefficient cleavage of the p55 precursor [12, 13]
	p24: 6
	p15: 3
*pol*	Pro: 3	Apparently intact [12]
	RT: 10
	Endo: 2
*env*	gp120: 4	No cleavage of the gp160 precursor [11, 12]
	gp41: 2
*nef*	3	Defects in trafficking and signaling functions [13, 14]
*tat*	0	Functional [12]
*rev*	0	Functional [12]
*vif*	14	Functionally defective [12, 15]
*vpr*	3	Premature stop codon at aa 76 [12]
*vpu*	0	Apparently intact [12]

^aThe F12/HIV-1 amino acid sequence was compared to a consensus sequence obtained with multiple alignments of 5 type B HIV-1 isolates. No nucleotide substitutions have been found in the LTRs, TAR, and RRE HIV-1 regulatory sequences.

ISSN: 1742-4690