Figure 4

The kinetics of bNAb interactions with SOSIP.664 trimers. The sensorgrams show binding titrations fitted with the bivalent model for all NAbs except 2G12 (Langmuir model). The colored curves show the response at analyte concentrations indicated to the right. Note that the color code is the same for all diagrams but that the titration ranges start and end at different concentrations and also differ in the dilution steps. The modeled curves in black are only visible when they diverge from the data. The sensorgrams show one of the multiples of replicates (n) given in Additional file 3: Table S5. In some experiments the dissociation phase had to be extended to 20 min to achieve significant values (T > 10) for k _d1 (not shown).