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Table 2 Inhibitory activity of SC29EK and MT-SC29EK against T20-resistant HIV-1 variants a

From: Two M-T hook residues greatly improve the antiviral activity and resistance profile of the HIV-1 fusion inhibitor SC29EK

  T20 SC29EK MT-SC29EK
HIV-1NL4–3 IC50 n-foldb IC50 n-fold IC50 n-fold
WT 52.1 ± 8.5 1 1.8 ± 0.2 1 0.6 ± 0.1 1
I37T 552.2 ± 123.4 10.6 15.0 ± 0.3 8.3 0.8 ± 0.2 1.3
V38A 1842.6 ± 56.1 35.4 16.2 ± 1.9 9 0.6 ± 0.1 1
V38M 378.3 ± 41.7 7.3 15.1 ± 1.8 8.4 1.7 ± 0.0 2.8
Q40H 1321.5 ± 92.3 25.4 83.8 ± 10.8 46.6 0.8 ± 0.1 1.3
N43K 366.8 ± 47.4 7 >250 >138.9 7.2 ± 0.2 12
D36S/V38M 202.6 ± 12.6 3.9 11.7 ± 0.7 6.5 1.2 ± 0.0 2
I37T/N43K >2250 >43 >250 >138.9 21.2 ± 4.4 35.3
V38A/N42T >2250 >43 37.7 ± 6.4 20.9 0.6 ± 0.0 1
  1. aThe data were derived from the results of three independent experiments and expressed as means ± SD. bn-fold values are relative to the IC50 of the wild-type (WT) virus.