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Table 1 Anti-HIV activity of MT-SC29EK and control peptides a

From: Two M-T hook residues greatly improve the antiviral activity and resistance profile of the HIV-1 fusion inhibitor SC29EK

   IC50 (nM)
Inhibitor Length (a.a.) Entry Replication
T20 36 73.2 ± 9.1 48.6 ± 1.2
C34 34 2.7 ± 0.1 1.3 ± 0.2
SFT 36 2.6 ± 0.1 1.5 ± 0.1
CP32M 32 1.8 ± 0.2 1.0 ± 0.2
T1249 39 1.4 ± 0.2 1.2 ± 0.2
T2635 38 1.1 ± 0.1 0.4 + 0.2
SC22EK 22 51.3 + 5.4 58.2 + 15.2
MT-SC22EK 24 2.1 ± 0.2 1.1 ± 0.1
SC29EK 29 2.2 ± 0.3 0.9 ± 0.2
MT-SC29EK 31 0.7 ± 0.0 0.2 ± 0.0
  1. aThe data were derived from the results of three independent experiments and expressed as means ± SD; a.a. means the number of amino acids.