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Figure 2 | Retrovirology

Figure 2

From: HIV-1 Vif N-terminal Motif is required for recruitment of Cul5 to Suppress APOBEC3

Figure 2

Several Vif N-terminal mutants are unable to degrade APOBEC3G and APOBEC3F. Vif wild-type and mutant proteins along with A3G or A3F were overexpressed in HEK 293 T cells. Two days post-transfection, cells were lysed and proteins were separated by SDS-PAGE and visualized by western blotting. A) APOBEC3F-V5 and B) APOBEC3G-V5 are efficiently degraded by wild-type Vif, but not by several Vif N-terminal mutants in HEK 293 T cells.

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