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Figure 6 | Retrovirology

Figure 6

From: Novel principles of gamma-retroviral insertional transcription activation in murine leukemia virus-induced end-stage tumors

Figure 6

The colocalization of integrations with enhancers is tissue-specific. The figure shows the distribution of promoter-distal integrations relative to enhancer midpoints determined from lymphoid (i.e. spleen and thymus) H3K4Me1 and H3K27Ac ChIP-seq peaks. The results from H3K4Me1 and H3K27Ac control datasets from brain (i.e. cerebellum and cortex) shows a substantial distortion in the distribution of integrations relative to enhancer midpoints. The RNA-seq integrations supported by chimeric fusions show a tissue-specific distribution that is comparable to the larger integration sets.

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