Figure 8

In vivo association of inflammasome-related genes with neurological disease in FIV [+] animals. A. Relative fold change (RFC) in mRNA expression of inflammasome- related and immune genes in the cortex and striatum of FIV [+] (n = 6) and FIV [-] (n = 10) animals at 12 weeks post-infection. Mean RFC values are reported. Bars indicate standard error. *indicate p-value of <0.05. B. Principal component analysis (PCA) comparing 49 clinical, neurobehavioral and molecular variables in FIV [-] and FIV [+] animals. PC1 represents the separation of the FIV [-] and FIV [+] animals while PC2 represents intra-group variance. C. Hierarchical Cluster Analysis of multivariate similarities between variables and animals. Only variables that significantly contributed to PC1 (infection status) are presented in the heat map.