Expression of inflammasome components and substrates in the HIV-1 infected human brain. A. Relative fold change (RFC) in mRNA expression in the white matter of persons with HIV-1 infection (HIV [+]) (n = 12) compared to other disease controls (HIV [-]) (n = 12), as measured by semi-quantitative real-time PCR. Mean values are reported. Bars indicate standard error. *indicate p-value of <0.05. B. Immunohistochemistry staining of cerebral white matter sections from other disease control (HIV [-]) and HIV-infected (HIV [+]) (200X view). Inset 'i’ represents double immunostaining for MHC II and IL-1β. Insets 'ii’, 'iii’ and 'iv’ are magnified images of the indicated cells within the HIV [+] section.