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Figure 1 | Retrovirology

Figure 1

From: Impact of amino acid substitutions in the V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 on viral neutralization susceptibility to broadly neutralizing antibodies specific for the CD4 binding site

Figure 1

The b12 susceptibility of N-linked glycan mutants of AE-Env clones. Amino acid substitutions, N197Q, N301Q, N339Q, N386Q and N392Q were introduced into AE-Env clones, 21PL2 (A), 22PL1 (B), 50PB2 (C), 98CC2 (D) and 104PB4 (E). Then, the b12 susceptibility of recombinant viruses containing wild-type and mutant AE-Env clones was evaluated as described in Methods. The results are expressed as percent neutralization, which was calculated by determining the reduction in viral infectivity in the presence of b12 compared to that in control experiments in the absence of b12. All data points are the means and standard errors (error bars) of at least two independent experiments.

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Retrovirology

ISSN: 1742-4690

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