Table 1 Ingenuity systems pathway analysis of genes found modulated by HIV and Tat in primary iDC and MDM
Ingenuity canonical pathways | p-value | ||
|---|---|---|---|
| Â | iDC | MDM | Common to both |
Interferon signaling | 7.59E-09 | 9.94E-10 | 2.54E-11 |
Pathogenesis of multiple sclerosis | 4.44E-08 | 1.45E-07 | 1.05E-09 |
Role of pattern recognition receptors in recognition of bacteria and viruses | 1.24E-06 | 3.95E-07 | 2.51E-07 |
Activation of IRF by cytosolic pattern recognition receptors | 9.36E-06 | 3.87E-05 | 4.93E-06 |
Ingenuity biological functions | Â | Â | Â |
Antimicrobial response | 8.44E-12 | 2.68E-10 | 2.82E-11 |
Cell-mediated immune response | 2.35E-10 | 7.57E-08 | 1.23E-10 |
Immune cell trafficking | 2.35E-10 | 7.57E-08 | 1.23E-10 |
Infection mechanism | 4.35E-08 | 1.45E-07 | 1.05E-09 |
Antigen presentation | 4.10E-09 | 7.72E-07 | 2.09E-08 |