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Figure 4 | Retrovirology

Figure 4

From: Diverse viral glycoproteins as well as CD4 co-package into the same human immunodeficiency virus (HIV-1) particles

Figure 4

Diverse viral glycoproteins can be co-packaged. Co-capture was performed using all paired combinations of HIV-1 Env, MLV Env, RSV Env, VSV-G and Ebola GP. Graphs show the luciferase signal from infection mediated by A) HIV-1 Env in TZM-bl cells, B) MLV Env in 293 T mCAT-1 cells, C) RSV Env in 293 T TVA cells, D) VSV-G in 293 T-derived cells or E) Ebola GP in 293 T-derived cells when virus was produced with the above glycoproteins and then captured with the indicated antibody. Red text with a # indicate the use of an entry defective VSV-G or Ebola GP as the target for capture. Signal was normalized to the straight infection for each experiment prior to averaging. The average fold increase from antibody capture/no antibody capture is shown for each co-capture sample. F) The average percent capture for each paring relative to the straight infection is shown. All graphs are the average of at least three independent experiments and standard deviations are shown. *p < 0.05; **p < 0.01; NS p > 0.05.

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